Depression Treatment Options at Actify

Actify’s treatment teams are able to create tailored care plans for each patient’s needs. We firmly believe that behavioral health treatment is not a “one-size-fits-all” solution and that not every treatment option is right for every patient. Your first appointment at Actify will include an in-depth consult with a mental health care provider to set up a treatment plan. When it comes to treating depression, we take into account patient history, previous treatment trials, and the way symptoms present in each case. Most of our treatment options are covered by insurance, too.

Ketamine Infusion Therapy
Spravato (Esketemine Nasal Spray)
Cognitive Behavioral Therapy

Ketamine Infusion Therapy

Ketamine infusion therapy is a treatment option for depression. Some people do not respond sufficiently to traditional treatment plans, which usually consist of SSRI antidepressants and talk therapy. Patients are connected to an IV and administered a very low dose of ketamine for about 40 minutes. Potential side effects may occur during the infusion including nausea, elevation of blood pressure, dissociation, or headache. Ketamine infusion therapy is a safe, evidence-based, rapid-acting option to help manage treatment-resistant depression.

Spravato (Esketemine Nasal Spray)

Spravato (nasal esketamine) has been FDA-approved for the treatment of depression in patients who have not responded to 2 or more treatments. This is the first truly new FDA-approved medication option for depression in 60 years. Esketamine, also called s-ketamine, is “one half” of ketamine ⁠— the other half being r-ketamine, its mirror image molecule. Spravato is a nasal spray, administered in an Actify office setting, that may more rapidly treat symptoms than SSRI medications. Side effects may be experienced for about an hour while taking it; side effects may include a dreamlike or “floaty” feeling, nausea, headache, or brief and mild elevations in blood pressure. There is a 2-hour observation time after nasal administration. Spravato is covered by some insurers for depression treatment.


Transcranial Magnetic Stimulation (TMS) is an FDA-approved treatment for depression that is a non-invasive, in-office, well-tolerated procedure. TMS uses an MRI-strength magnetic coil to deliver a low-energy pulse to a targeted area of the brain. This is a non-invasive procedure that does not involve medication. Treatment is delivered on a Monday through Friday basis for 4-6 weeks for about 30 minutes, and then tapered off. Results are typically seen within the first 2-3 weeks. TMS is directly insurance-covered by most plans for treatment resistant depression.

Cognitive Behavioral Therapy

Cognitive behavioral therapy (CBT) is a skill-based talk therapy focused on the relationship between a person’s thoughts, feelings and behaviors. Individuals with depression often have pervasive, unrealistic, negative thoughts that adversely shape the way they view themselves, their environment and their prospects for the future. These thoughts can interfere with relationships or level of functioning. CBT aims to provide a set of tools that allow the patient to manage negative thoughts by doing things like questioning the validity of these thoughts, altering one’s negative core beliefs, and ultimately changing one’s behaviors.

Common Symptoms of Depression

Depression can manifest in different ways depending on a variety of factors. The most common symptom of depression is not finding pleasure or satisfaction in activities that once held your interest.

Some more symptoms of depression include:

  • Decreased energy
  • Appetite or weight changes
  • Persistent sad or “empty” mood
  • Feelings of hopelessness
  • Suicidal thoughts or behavior

How to Know When to Seek Help

Most people feel sad from time to time – it’s normal, but when symptoms persist for more than two weeks and start to impact your ability to maintain your relationships and responsibilities it’s time to reach out. It doesn’t matter if this is your first time having these symptoms or if you’ve experienced depression in the past – there is help available. Depression is treatable, but when left untreated symptoms can worsen. Even if you’ve had trouble finding the right treatment in the past, Actify can help you.

Take a look at our Locations to find an Actify office near you. We’re ready to help you rediscover yourself with the most advanced mental health care available.


More Than 5,000 Success Stories

Actify always makes me feel comfortable, provides exceptional care and makes my experience stress-free and therapeutic.
There are no reviews high enough to describe the support, care, and compassion I have received from every person at Actify. The center and staff have given me hope… something I have not felt in some time. Exceptional care.
I can’t recommend the Actify enough. Their clinicians are highly knowledgeable, non-judgemental, and keep up-to-date on the science. Their nursing staff is exceptional. If you’re considering infusions, this is the place to be!
I have lived with PTSD and all that comes with it almost my entire life. I’m now 56 and I can finally say that I’m filled with joy and hope because of Actify Neurotherapies. The results are nothing short of a miracle. I have a “normal” life for the first time and you cannot put a price on that.
The staff at Actify are beyond professional and excellent – they truly CARE about you as a patient and a person. I was at first a bit nervous about going on this “journey” but I am so glad I did. This treatment and the people here have given me hope – something I have not felt in the longest time about my illness.
Actify has helped me change my life. They offer an effective alternative approach to treating depression and anxiety. After 8 years of struggling and suffering, I’ve finally found a treatment that works.
Actify has changed the entire game! They are looking at depression outside of the pill box and looking at contemporary treatments that last without taking antidepressants.


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Our team is available day or night to connect you with the safest, most advanced mental health care. Click or tap the chat button below to get started.

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